2017

List of publications (non-exhaustive list)

  • Le Gac G, Angenard G, Clément B, Laviolle B, Coulouarn C, Beloeil H. Local Anesthetics Inhibit the Growth of Human Hepatocellular Carcinoma Cells. Anesth Analg. 2017 Nov;125(5):1600-1609.
  • Séhédic D, Chourpa I, Tétaud C, Griveau A, Loussouarn C, Avril S, Legendre C, Lepareur N, Wion D, Hindré F, Davodeau F, Garcion E. Locoregional Confinement and Major Clinical Benefit of 188Re-Loaded CXCR4-Targeted Nanocarriers in an Orthotopic Human to Mouse Model of Glioblastoma. Theranostics. 2017 Oct 12;7(18):4517-4536
  • Carné Trécesson S, Souazé F, Basseville A, Bernard AC, Pécot J, Lopez J, Bessou M, Sarosiek KA, Letai A, Barillé-Nion S, Valo I, Coqueret O, Guette C, Campone M, Gautier F, Juin PP. BCL-XL directly modulates RAS signalling to favour cancer cell stemness. Nat Commun. 2017 Oct 24;8(1):1123.
  • Mathot P, Grandin M, Devailly G, Souaze F, Cahais V, Moran S, Campone M, Herceg Z, Esteller M, Juin P, Mehlen P, Dante R. DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment. Oncogenesis. 2017 Oct 23;6(10):e390.
  • Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, Scotet E, Rabe M, Alves-Guerra MC, Teusan R, Gautier F, Loussouarn D, Compan V, Martinou JC, Vallette FM, Pecqueur C. Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity. Clin Cancer Res. 2017 Oct 15;23(20):6292-6304.
  • Barroso MV, Cattani-Cavalieri I, de Brito-Gitirana L, Fautrel A, Lagente V, Schmidt M, Porto LC, Romana-Souza B, Valença SS, Lanzetti M. Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2. Bioorg Med Chem. 2017 Oct 15;25(20):5557-5568.
  • Voissiere A, Weber V, Gerard Y, Rédini F, Raes F, Chezal JM, Degoul F, Peyrode C, Miot-Noirault E. Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept. Oncotarget. 2017 Sep 27;8:95824-95840.
  • Gomez-Brouchet A, Illac C, Gilhodes J, Bouvier C, Aubert S, Guinebretiere JM, Marie B, Larousserie F, Entz-Werlé N, de Pinieux G, Filleron T, Minard V, Minville V, Mascard E, Gouin F, Jimenez M, Ledeley MC, Piperno-Neumann S, Brugieres L, Rédini F. CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial. Oncoimmunology. 2017 Aug 24;6:e1331193
  • Ancey PB, Ecsedi S, Lambert MP, Talukdar FR, Cros MP, Glaise D, Narvaez DM, Chauvet V, Herceg Z, Corlu A, Hernandez-Vargas H. TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors. Stem Cell Reports. 2017 Jul 11;9(1):264-278.
  • Garnier A, Guillaume T, Peterlin P, Béné MC, Le Bris Y, Dubruille V, Mahé B, Gastinne T, Touzeau C, Blin N, Le Gouill S, Moreau P, Chevallier P. Second-degree relative donors for T-replete haploidentical allogeneic stem cell transplantation with high-dose post-transplant cyclophosphamide: toward crossing the major HLA barrier. Bone Marrow Transplant. 2017 Jul;52(7):1063-1064.
  • Lafargue A, Degorre C, Corre I, Alves-Guerra MC, Gaugler MH, Vallette F, Pecqueur C, Paris F. Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. Free Radic Biol Med. 2017 Jul;108:750-759.
  • Papin A, Le Gouill S, Chiron D. Rationale for targeting tumor cells in their microenvironment for mantle cell lymphoma treatment. Leuk Lymphoma. 2017 Jul 31:1-9.
  • Ondet T, Muscatelli-Groux B, Coulouarn C, Robert S, Gicquel T, Bodin A, Lagente V, Grimaud JA. The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):827-838.
  • Victoni T, Salvator H, Abrial C, Brollo M, Porto LCS, Lagente V, Naline E, Grassin-Delyle S, Devillier P. Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release. Respir Res. 2017 Jun 21;18(1):126.
  • Klimkiewicz K, Weglarczyk K, Collet G, Paprocka M, Guichard A, Sarna M, Jozkowicz A, Dulak J, Sarna T, Grillon C, Kieda C. A 3D model of tumourangiogenic microenvironment to monitor hypoxia effects on cell interactions and cancer stem cell selection.Cancer Lett. 2017 Jun 28;396:10-20.
  • Niaudet C, Bonnaud S, Guillonneau M, Gouard S, Gaugler MH, Dutoit S, Ripoche N, Dubois N, Trichet V, Corre I, Paris F. Plasma membrane reorganization links acid sphingomyelinase/ceramide to p38 MAPK pathways in endothelial cells apoptosis. Cell Signal. 2017 May;33:10-21.
  • Poupard N, Badarou P, Fasani F, Groult H, Bridiau N, Sannier F, Bordenave-Juchereau S, Kieda C, Piot JM, Grillon C, Fruitier-Arnaudin I, Maugard T. Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti AngiogenicAgent.Mar Drugs. 2017 May 9;15(5). pii: E134.
  • Corre I, Paris F, Huot J. The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells. Oncotarget. 2017 May 29;8(33):55684-55714.
  • Tejchman A, Lamerant-Fayel N, Jacquinet JC, Bielawska-Pohl A, Mleczko-Sanecka K, Grillon C, Chouaib S, Ugorski M, Kieda C.Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization.Oncotarget. 2017 May 9;8(19):31876-31887.
  • Niaudet C, Bonnaud S, Guillonneau M, Gouard S, Gaugler MH, Dutoit S, Ripoche N, Dubois N, Trichet V, Corre I, Paris F. Plasma membrane reorganization links acid sphingomyelinase/ceramide to p38 MAPK pathways in endothelial cells apoptosis. Cell Signal. 2017 May;33:10-21.
  • Paul-Gilloteaux P, Potiron V, Delpon G, Supiot S, Chiavassa S, Paris F, Costes SV. Optimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes. Sci Rep. 2017 May 23;7(1):2280
  • Dornas WC, Cardoso LM, Silva M, Machado NL, Chianca DA Jr, Alzamora AC, Lima WG, Lagente V, Silva ME.Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments.Sci Rep. 2017 Apr 11;7:46051.
  • El-Habr EA, Dubois LG, Burel-Vandenbos F, Bogeas A, Lipecka J, Turchi L, Lejeune FX, Coehlo PL, Yamaki T, Wittmann BM, Fareh M, Mahfoudhi E, Janin M, Narayanan A, Morvan-Dubois G, Schmitt C, Verreault M, Oliver L, Sharif A, Pallud J, Devaux B, Puget S, Korkolopoulou P, Varlet P, Ottolenghi C, Plo I, Moura-Neto V, Virolle T, Chneiweiss H, Junier MP. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. Acta Neuropathol. 2017 Apr;133(4):645-660.
  • Hochane M, Trichet V, Pecqueur C, Avril P, Oliver L, Denis J, Brion R, Amiaud J, Pineau A, Naveilhan P, Heymann D, Vallette FM, Olivier C. Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC. Stem Cells. 2017 Mar;35(3):800-811.
  • Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B. Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure. Environ Toxicol. 2017 Mar;32(3):1024-1036.
  • Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B. Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics. Hypoxia (Auckl). 2017 Mar 15;5:11
  • Krawczenko A, Bielawska-Pohl A, Wojtowicz K, Jura R, Paprocka M, Wojdat E, Kozłowska U, Klimczak A, Grillon C, Kieda C, Duś D.Expression and activity of multidrug resistance proteins in mature endothelial cells and their precursors: A challenging correlation.PLoS One. 2017 Feb 17;12(2):e0172371
  • Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B.Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure.Environ Toxicol. 2017 Mar;32(3):1024-1036. Le Flahec G, Uguen M, Uguen A. Detection of MismatchRepairDeficiency in Colorectal Cancers: Is It Really Time to EliminateImmunohistochemistry? J Clin Oncol. 2017 Jan 20;35(3):376-377.
  • Crenn V, Biteau K, Amiaud J, Dumars C, Guiho R, Vidal L, Nail LL, Heymann D, Moreau A, Gouin F, Redini F. Bone microenvironment has an influence on the histological response of osteosarcoma to chemotherapy: retrospective analysis and preclinical modeling.. Am J Cancer Res. 2017 1;7:2333-2349.
  • Brennan MA, Renaud A, Guilloton F, Mebarki M, Trichet V, Sensebé L, Deschaseaux F, Chevallier N, Layrolle P. Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose Tissue-Compared with Bone Marrow-Derived Stromal Stem Cells Cultured in Xeno-Free Conditions. Stem Cells Transl Med. 2017 6:2160-2172.
  • Desert R,Reynes C, Sabatier R, Gregoire D, Rohart F, Corlu A, Canal F, Sicard M, Desille M, Renaud S, Turlin B, Sulpice L, Bergeat D, Bellaud P, Perret C, Clement B, Lê Cao KA, Musso O. Phenotypic diversity spanning the spectrum of hepatocyte differentiation impacts the outcome of patients with beta-catenin-mutated hepatocellular carcinomas. Hepatology, Wiley-Blackwell, 2017, 66, pp.129A-129A.
  • Silva C, Monte-Alto-Costa A, Renovato-Martins M, Viana Nascimento FJ, Dos Santos Valença S, Lagente V, Pôrto LC, Victoni T. Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo. International Journal of Molecular Sciences, MDPI, 2017, 18 (9), pp.1940.
  • Le Corvec M, Jezequel C, Monbet V, Fatih N, Charpentier F, Tariel H, Boussard-Plédel C, Bureau B, Loreal O, Sire O, Bardou-Jacquet E. Mid-infrared spectroscopy of serum, a promising non-invasive method to assess prognosis in patients with ascites and cirrhosis. PLoS ONE (2017) 12, e0185997
  • Raggi C, Correnti M, Sica A, Andersen JB, Cardinale V, Alvaro D, Chiorino G, Forti E, Glaser S, Alpini G, Destro A, Sozio F, Di Tommaso L, Roncalli M, Banales JM, Coulouarn C, Bujanda L, Torzilli G, Invernizzi P. Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages. J Hepatol. 2017 66:102-115
  • Bevant K, Coulouarn C. Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies. Hepatobiliary Surg Nutr. 2017 6:404-407
  • Abitbol S, Dahmani R, Coulouarn C, Ragazzon B, Mlecnik B, Senni N, Bossard P, Sohier P, Wang W, Grimber G, Drouet V, Tournier E, Dumont F, Just PA, Terris B, Perret C and Gilgenkrantz H. Axin1 deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of beta-catenin activation. J. Hepatol. (2018, In Press)
  • Merdrignac A, Angenard G, Allain C, Petitjean K, Bergeat D, Bellaud P, Fautrel A, Turlin B, Clément B, Dooley S, Sulpice L, Boudjema K, Coulouarn C. TLINC, a novel TGF-beta-induced long non coding RNA, promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma. Hepatology Communications (2018, In Press)
  • Barbarin A, Cayssials E, Jacomet F, Nunez NG, Basbous S, Lefèvre L, Abdallah M, Piccirilli N, Morin B, Lavoué V, Catros V, Piaggio E, Herbelin A, Gombert JM. Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases. Frontiers in Immunology, Frontiers, 2017, 8, pp.316
  • Durand S, Trillet K, Uguen A, Saint-Pierre A, Le Jossic-Corcos C, Corcos L. A transcriptome-based protein network that identifies new therapeutic targets incolorectal cancer. BMC Genomics. 2017 Sep 30;18(1):758.
  • Le Flahec G, Badic B, Guibourg B, Doucet L, Bail JP, Marcorelles P, Schick U, Uguen A. Mismatch repair-deficient colorectal cancer: a model of immunogenic and immune cell-rich tumor despite non-significant PD-L1 expression in tumor cells.Hum Pathol. 2018 Feb;72:135-143.
  • Harford-Wright E, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D, Oliver L, Vallette FM, Foufelle F, Valet P, Davenport AP, Glen RC, Bidere N, Gavard J. Pharmacological targeting of apelin impairs glioblastoma growth. Brain; 11(1): 2939–54.
  • Jacobs KA, Harford-Wright E, Gavard J. Neutralizing gp130 interferes with endothelial-mediated effects on glioblastoma stem-like cells. Cell Death Diff. 2017; 24(2): 384.
  • Treps L, Perret R, Edmond S, Ricard D, Gavard J. Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extracellular vesicles. J Extracell Vesicles. 2017; 6(1): 1359479.
  • André-Grégoire G, Gavard J. Spitting out the demons: Extracellular vesicles in glioblastoma. Cell Adh Migr. 2017; 11(2): 164-172.
  • Juen L, Brachet-Botineau M, Parmenon C, Bourgeais J, Herault O, Gouilleux F, Viaud-Massuard MC, Prié G. A new inhibitor targeting signal transducer and activator of transcription 5 (STAT5) signaling in myeloid leukemias. J Med Chem 2017, 60:6119-6136
  • Desbourdes L, Javary J, Charbonnier T, Ishac N, Bourgeais J, Iltis A, Chomel JC, Turhan A, Guilloton F, Tarte K, Demattei MV, Ducrocq E, Rouleux-Bonnin F, Gyan E, Herault O, Domenech J. Alteration analysis of bone marrow mesenchymal stromal cells from de novo acute myeloid leukemia patients at diagnosis. Stem Cell Dev 2017, 26:709-722
  • Ghanem S, Friedbichler K, Boudot C, Bourgeais J, Gouilleux-Gruart V, Regnier V, Herault O, Moriggl R, Gouilleux F. STAT5A/5B-specific expansion and transformation of hematopoietic stem cells. Blood Cancer J 2017, 7:e514
  • Bourgeais J, Ishac N, Medrzycki M, Brachet-Botineau M, Desbourdes L, Gouilleux-Gruart V, Pecnard E, Rouleux-Bonnin F, Gyan E, Domenech J, Mazurier F, Moriggl R, Bunting KD, Herault O, Gouilleux F. Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses. Oncotarget 2017, 8:41876-41889
  • Aggoune D, Sorel N, Bonnet ML, Goujon JM, Tarte K, Hérault O, Domenech J, Réa D, Legros L, Johnson-Ansa H, Rousselot P, Cayssials E, Guerci-Bresler A, Bennaceur-Griscelli A, Chomel JC, Turhan AG. (2017) Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs). Leuk Res, 60:94-102
  • Cheloni G, Tanturli M, Tusa I, DeSouza NH, Shan Y, Gozzini A, Mazurier F, Rovida E, Li S, Dello Sbarba P. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood 2017, 130:655-666
  • Nguyen PH, Charbonnier L, Giraud J, Dubus P, Wittkop L, Belleannée G, Collet D, Soubeyran I, Evrard S, Rousseau B, Senant-Dugot N, Mégraud F, Mazurier F, Varon C. Characterization of biomarkers of tumorigenic and chemoresistant cancer cells in human gastric carcinoma. Clin Cancer Res 2017, 23:1586-1597
  • Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM. p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors. Oncogene. 2017 Apr 27;36(17):2355-2365.
  • Aggoune D, Sorel N, Bonnet ML, Goujon JM, Tarte K, Hérault O, Domenech J, Réa D, Legros L, Johnson-Ansa H, Rousselot P, Cayssials E, Guerci-Bresler A, Bennaceur-Griscelli A, Chomel JC, Turhan AG. Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs). Leukemia Research, Elsevier, 2017, 60, pp.94-102
  • Bertheuil N, Varin A, Carloni R, Girard P, Chaput B. Mechanically Isolated Stromal Vascular Fraction by Nanofat Emulsification Techniques. Plastic and Reconstructive Surgery, Lippincott, Williams & Wilkins, 2017, 140 (3), pp.508e-509e.
  • Chaput B, Bertheuil N, Grolleau JL, Garrido I, Laloze J, Varin A. Reply: Mechanical Isolation of Stromal Vascular Fraction: A New Advance in Stem Cell Therapy? Plastic and Reconstructive Surgery, Lippincott, Williams & Wilkins, 2017, 139, pp.573e--574e.
  • Desbourdes L, Javary J, Charbonnier T, Ishac N, Bourgeais J, Iltis A, Chomel JC, Turhan A, Guilloton F, Tarte K, Demattei MV, Ducrocq E, Rouleux-Bonnin F, Gyan E, Herault O, Domenech J. Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis. Stem Cells and Development, Mary Ann Liebert, 2017, 26 (10), pp.709-722.
  • Houot R, Marchand T, Dhédin N, Lescaut W, Thiebaut-Bertrand A, Francois S, Stamatoullas-Bastard A, Rohrlich PS, Labussière Wallet H, Castagna L, Santoro A, Bachanova V, Bresler SC, Srivastava A, Kim H, Pesek E, Chammas M, Reynolds C, Ho VT, Antin JH, Ritz J, Soiffer RJ, Armand P, Merryman RW, Kim HT, Zinzani PL, Carlo-Stella C, Ansell SM, Perales MA, Avigdor A, Halwani AS. Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma. Blood, 2017, 129, pp.1380-1388.
  • Loisel S, Dulong J, Menard C, Renoud ML, Meziere N, Isabelle B, Latour M, Bescher N, Pedeux R, Bertheuil N, Flecher E, Sensebe L, Tarte K. Proteasomal Indoleamine 2,3-Dioxygenase Degradation Reduces the Immunosuppressive Potential of Clinical Grade-Mesenchymal Stromal Cells Undergoing Replicative Senescence. Stem Cells / Stem Cells (Miamisburg), Alphamed Press, 2017, 35 (5), pp.1431-1436.
  • Uhel F, Camus C, Gacouin A, Tadié JM, Le Tulzo Y, Roussel M, Tarte K. Reply to: Tempering the Clinical Effects of Early Myeloid Derived Suppressor Cell Expansion in Severe Sepsis and Septic Shock. Am J Respir Crit Care Med, 2017
  • Hipp N, Symington H, Pastoret C, Caron G, Monvoisin C, Tarte K, Fest T, Delaloy C. IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression. Nat Commun, 2017, 8(1),1443
  • Clere N, Thien To KH, Legeay S, Bertrand S, Helesbeux JJ, Duval O, Faure S. Pro-angiogenic effects of low dose ethoxidine in a murine model of ischemic hindlimb : correlation between ethoxidine levels and increased activation of the nitric oxide pathway. 2017. Molecules. 22(4). pii: E627
  • Pautu V, Leonetti D, Lepeltier E, Clere N, Passirani C. Nanomedicine as a potent strategy in melanoma tumor microenvironment. 2017. Pharmacol Res. S1043-6618(17)30015-4
  • Legeay S, Billat PA, Clere N, Nesslany F, Bristeau S, Faure S, Mouvet C. Two chlorinated chlordecone derivatives formed by in situ chemical reduction are devoid of genotoxicity and mutagenicity and have lower pro-angiogenic properties compared to parent compound. 2017. Environ Sci Pollut Res.