2014

List of publications

  • Janel A, Dubois-Galopin F, Bourgne C, Berger J, Tarte K, Boiret-Dupré N, Boisgard S, Verrelle P, Déchelotte P, Tournilhac O, Berger MG. The chronic lymphocytic leukemia clone disrupts the bone marrow microenvironment. Stem Cells Dev. 2014 Dec 15;23(24):2972-82. - (MNT team: INSERM UMR 917 - Rennes)
  • Dubois-Pot-Schneider H, Fekir K, Coulouarn C, Glaise D, Aninat C, Jarnouen K, Le Guével R, Kubo T, Ishida S, Morel F, Corlu A. Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. Hepatology. 2014 Dec;60(6):2077-90. - (MNT team: INSERM UMR 991 - Rennes)
  • Chen KT, Pernelle K, Tsai YH, Wu YH, Hsieh JY, Liao KH, Guguen-Guillouzo C, Wang HW. Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α. J Hepatol. 2014 Dec;61(6):1276-86. - (MNT team: INSERM UMR 991 - Rennes)
  • Mazuryk O, Magiera K, Rys B, Suzenet F, Kieda C, Brindell M. Multifaceted interplay between lipophilicity, protein interaction and luminescence parameters of non-intercalative ruthenium(II) polypyridyl complexes controlling cellular imaging and cytotoxic properties. J Biol Inorg Chem. 2014 Dec;19(8):1305-16. - (MNT Team: CNRS UPR4301 - CBM - Orléans)
  • Gamblin AL, Renaud A, Charrier C, Hulin P, Louarn G, Heymann D, Trichet V, Layrolle P. Osteoblastic and osteoclastic differentiation of human mesenchymal stem cells and monocytes in a miniaturized three-dimensional culture with mineral granules.Acta Biomater. 2014 Dec;10(12):5139-47. - (MNT team: INSERM UMR 957 - Nantes)
  • Rossille D, Gressier M, Damotte D, Maucort-Boulch D, Pangault C, Semana G, Le Gouill S, Haioun C, Tarte K, Lamy T, Milpied N, Fest T. High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a french multicenter clinical trial. Leukemia. 2014 Dec;28(12):2367-75. - (MNT team: INSERM UMR 917 - Rennes)
  • Sungalee S, Mamessier E, Morgado E, Grégoire E, Brohawn PZ, Morehouse CA, Jouve N, Monvoisin C, Menard C, Debroas G, Faroudi M, Mechin V, Navarro JM, Drevet C, Eberle FC, Chasson L, Baudimont F, Mancini SJ, Tellier J, Picquenot JM, Kelly R, Vineis P, Ruminy P, Chetaille B, Jaffe ES, Schiff C, Hardwigsen J, Tice DA, Higgs BW, Tarte K, Nadel B, Roulland S. Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression. J Clin Invest. 2014 Dec;124(12):5337-51. - (MNT team: INSERM UMR 917 - Rennes)
  • Sulpice L, Rayar M, Turlin B, Boucher E, Bellaud P, Desille M, Meunier B, Clément B, Boudjema K, Coulouarn C. Epithelial cell adhesion molecule is a prognosis marker for intrahepatic cholangiocarcinoma. J Surg Res. 2014 Nov;192(1):117-23. - (MNT team: INSERM UMR 991 - Rennes)
  • Lézot F, Chesneau J, Battaglia S, Brion R, Farges JC, Heymann D, Rédini F. Preclinical evidence of potential craniofacial adverse effect of zoledronic acid in pediatric patients with bone malignancies. Bone. 2014 Nov;68:146-52. - (MNT team: INSERM UMR 957 - Nantes)
  • Lamora A, Talbot J, Bougras G, Amiaud J, Leduc M, Chesneau J, Taurelle J, Stresing V, Le Deley MC, Heymann MF, Heymann D, Rédini F, Verrecchia F. Over expression of Smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma. Clin Cancer Res. 2014 Oct 1;20(19):5097-112. - (MNT team: INSERM UMR 957 - Nantes)
  • Lamoureux F, Baud’Huin M, Ory B, Guiho R, Zoubeidi A, Gleave M, Heymann D, Rédini F. Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma. Oncotarget. 2014 Sep 15;5(17):7805-19. - (MNT team: INSERM UMR 957 - Nantes)
  • Tessoulin B, Descamps G, Moreau P, Maiga S, Lodé L, Godon C, Marionneau-Lambot S,Ouiller T, Le Gouill S, Amiot M, Pellat-Deceunynck C. PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance. Blood. 2014 Sep 4;124(10):1626-36. - (MNT team: INSERM UMR892/ CNRS U6299 Eq.10 - Nantes)
  • Cartron PF, Petit E, Bellot G, Oliver L, Vallette FM. Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis. Cell Signal. 2014 Sep;26(9):1928-34. - (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Pacaud R, Sery Q, Oliver L, Vallette FM, Tost J, Cartron PF. DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1. Biochimie. 2014 Sep;104:36-49. - (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Coulibaly WK, Paquin L, Benie A, Bekroy-A, Le Guevel R, Ravache M, Corlu A, Bazureau JP. Prospective study directed to the synthesis of unsymmetrical linked bis-5-arylidene rhodanine derivatives via ‘‘one-pot two steps’’ reactions under microwave irradiation with their antitumor activity. Medicinal Chemistry Research Sept 2014 - (MNT team: INSERM UMR 991 - Rennes)
  • Michel N, Heuzé-Vourc'h N, Lavergne E, Parent C, Jourdan ML, Vallet A, Iochmann S,Musso O, Reverdiau P, Courty Y. Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor. Biol Chem. 2014 Sep;395(9):1015-25. - (MNT team: INSERM UMR 991 - Rennes)
  • Surget S, Lemieux-Blanchard E, Maïga S, Descamps G, Le Gouill S, Moreau P, Amiot M, Pellat-Deceunynck C. Bendamustine and melphalan kill myeloma cells similarly through reactive oxygen species production and activation of the p53 pathway and do not overcome resistance to each other. Leuk Lymphoma. 2014 Sep;55(9):2165-73. - (MNT team: INSERM UMR892/ CNRS U6299 Eq.10 - Nantes)
  • Dagher J, Dugay F, Rioux-Leclercq N, Verhoest G, Oger E, Bensalah K, Cabillic F, Kammerer-Jacquet Sf, Fergelot P, Vigneau C, Arlot-Bonnemains Y, Belaud-Rotureau MA. Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival. Hum Pathol. 2014 Aug;45(8):1639-46. - (MNT team: INSERM UMR 991 - Rennes)
  • Dianat N , Dubois-Pot-Schneider H, Steichen C, Desterke C, Leclerc P, Raveux A, Combettes L, Weber A, Corlu A*, Dubart-Kupperschmitt*. A Generation of functional cholangiocytelike cells from human pluripotent stem cells and HepaRG cells. Hepatology. 2014 Aug;60(2):700-14. - (MNT team: INSERM UMR 991 - Rennes)
  • Malinen MM, Kanninen LK, Corlu A, Isoniemi HM, Lou YR, Yliperttula ML, Urtti AO. Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels. Biomaterials. 2014 Jun;35(19):5110-21. - (MNT team: INSERM UMR 991 - Rennes)
  • Nanbakhsh, A., Pochon, C., Amsellem, S., Pittari, G., Tejchman, A., Bourhis, J.H. and Chouaib, S. Enhanced Cytotoxic Activity of Ex Vivo-differentiated Human Natural Killer Cells in the Presence of HOXB4. J Immunother. 2014 Jun;37(5):278-82.- (MNT Team: CNRS UPR4301 - CBM - Orléans)
  • Coulouarn C and Clément B. Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma. J Hepatol. 2014 Jun;60(6):1306-9.- (MNT team: INSERM UMR 991 - Rennes)
  • Cheray M, Nadaradjane A, Bonnet P, Routier S, Vallette FM, Cartron PF. Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness. Epigenomics. 2014 Jun;6(3):267-­‐75.- (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Tellier J, Menard C, Roulland S, Martin N, Monvoisin C, Chasson L, Nadel B, Gaulard P, Schiff C, Tarte K. Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis? Blood. 2014 May 29;123(22):3462-5. (MNT team: INSERM UMR 917 - Rennes)
  • Mignard V, Lalier L, Paris F, Vallette FM. Bioactive lipids and the control of Bax proapoptotic activity. Cell Death Dis. 2014 May 29;5:e1266. (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Gratas C, Séry Q, Rabé M, Oliver L, Vallette FM. Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma. Oncotarget. 2014 May 15;5(9):2428-35. (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Gallouet AS, Travert M, Bresson-Bepoldin L, Guilloton F, Pangault C, Caulet-Maugendre S, Lamy T, Tarte K, Guillaudeux T. COX-2 independent effects of Celecoxib sensitize Lymphoma B cells to TRAIL-mediated apoptosis. Clin Cancer Res. 2014 May 15;20(10):2663-73. (MNT team: INSERM UMR 917 - Rennes)
  • Tertil, M., Skrzypek, K., Florczyk, U., Weglarczyk, K., Was, H., Collet, G., Guichard, A., Gil, T., Kuzdzal, J., Jozkowicz, A., Kieda, C., Pichon, C. and Dulak, J. Regulation and Novel Action of Thymidine Phosphorylase in Non-Small Cell Lung Cancer : Crosstalk with Nrf2 and HO-1 PLoS One. 2014 May 12;9(5):e97070. - (MNT Team: CNRS UPR4301 - CBM -Orléans)
  • Merdrignac A, Sulpice L, Rayar M, Rohou T, Quehen E, Zamreek A, Boudjema K, Meunier B. Pancreatic head cancer in patients with chronic pancreatitis. Hepatobiliary Pancreat Dis Int. 2014 Apr;13(2):192-7. - (MNT team: INSERM UMR 991 - Rennes)
  • Gobin B, Battaglia S, Lanel R, Chesneau J, Amiaud J, Redini F, Ory B, Heymann D. NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate. Cancer Lett. 2014 Mar 28;344(2):291-8. - (MNT team: INSERM UMR 957 - Nantes)
  • Galan-Moya EM, Treps L, Oliver L, Chneiweiss H, Vallette FM, Bidère N, Gavard J. Endothelial secreted factors suppress mitogen deprivation-induced autophagy and apoptosis in glioblastoma stem-like cells. PLoS One. 2014 Mar 28;9(3):e93505. - (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Lamoureux F, Baud'huin M, Rodriguez Calleja L, Jacques C, Berreur M, Rédini F, Lecanda F, Bradner JE, Heymann D, Ory B. Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle. Nat Commun. 2014 Mar 19;5:3511. - (MNT team: INSERM UMR 957 - Nantes)
  • Pacaud R, Brocard E, Lalier L, Hervouet E, Vallette FM, Cartron PF. The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures. Sci Rep. 2014 Mar 18;4:4230. - (MNT team: INSERM UMR892/CNRS U6299 Eq.9 - Nantes)
  • Odri GA, Kim PP, Lamoureux F, Charrier C, Battaglia S, Amiaud J, Heymann D, Gouin F, Rédini F. Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing's sarcoma via inhibition of cell migration. BMC Cancer. 2014 Mar 10;14:169. - (MNT team: INSERM UMR 957 - Nantes)
  • Ben Mosbah I, Duval H, Mbatchi SF, Ribault C, Grandadam S, Pajaud J, Morel F, Boudjema K, Compagnon P*, Corlu A** Intermittent selective clamping improves rat liver regeneration by attenuating oxidative and endoplasmic reticulum stress. Cell Death Dis. 2014 Mar 6;5:e1107. - (MNT team: INSERM UMR 991 - Rennes)
  • Gobin B, Moriceau G, Ory B, Charrier C, Brion R, Blanchard F, Rédini F, Heymann D. Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models. PLoS One. 2014 Mar 5;9(3):e90795. - (MNT team: INSERM UMR 957 - Nantes)
  • Berger A, Hoelbl-Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E, Uras I, Menzl I, Putz E, Hoermann G, Schuster C, Fajmann S, Leitner E, Kubicek S, Moriggl R, Gouilleux F, Sexl V. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia. 2014 Mar;28(3):629-41. - (MNT team: CNRS UMR 7292 LNOx - Tours)
  • Cabillic F, Gros A, Dugay F, Begueret H, Mesturoux L, Chiforeanu Dc, Dufrenot L, Jauffret J, Dachary D, Corre R, Lespagnol A, Soler G, Dagher J, Catros V, Le Calve M, Merlio JP,Belaud-Rotureau MA. Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances.J Thorac Oncol. 2014 Mar;9(3):295-306. - (MNT team: INSERM UMR 991 - Rennes)
  • Saurat T, Buron F, Rodrigues N, De Tauzia Ml, Colliandre L, Bourg S, Bonnet P, Guillaumet G, Akssira M, Corlu A, Guguen-Guillouzo C, Berthier P, Rio P, Jourdan Ml, Benedetti H, Routier S. Design, Synthesis and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/ mTOR Dual Inhibitors.J Med Chem. 2014 Feb 13;57(3):613-31. - (MNT team: INSERM UMR 991 - Rennes)
  • Amé-Thomas P, Tarte K. The yin and the yang of follicular lymphoma cell niches: Role of microenvironment heterogeneity and plasticity. Semin Cancer Biol. 2014 Feb;24:23-32.(MNT team: INSERM UMR 917 - Rennes)
  • Morfouace M , Lalier L, Oliver L, Cheray M, Pecqueur C, Cartron PF, Vallette FM. Control of glioma stem cell death and differentiation by a PKM2-Oct4 complex. Cell Death Dis. 2014 Jan 30;5:e1036.- (MNT team: INSERM UMR892/ CNRS U6299 Eq.9 - Nantes)
  • Collet G., Lamerant-Fayel N., Tertil M., El Hafny-Rahbi B., Stepniewski J., Guichard A., Foucault-Collet A., Klimkiewicz K., Petoud S., Matejuk A., Grillon C., Jozkowicz A., Dulak J. and Kieda C. Hypoxia-Regulated Overexpression of Soluble VEGFR2 Controls Angiogenesis and Inhibits Tumor Growth. Mol Cancer Ther. 2014 Jan;13(1):165-78. - (MNT Team: CNRS UPR4301 - CBM - Orléans)
  • Ilboudo A, Nault JC, Dubois-Pot-Schneider H, Corlu A, Zucman-Rossi J, Samson M, Le Seyec J. Overexpression of phosphatidylinositol 4‐kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma. BMC Cancer. 2014 Jan 6;14:7.- (MNT team: INSERM UMR 991 - Rennes)
  • Collet, G. Robert, E. Lenoir, A. Vandamme, M. Darny, T. Dozias, S. Kieda, C. Pouvesle, J. M. Plasma jet-induced tissue oxygenation : potentialities for new therapeutic strategie. Plasma Sources Science and Technology. 23 (1) - (MNT Team: CNRS UPR4301 - CBM - Orléans)
  • Téletchéa S, Stresing V, Hervouet S, Baud'huin M, Heymann MF, Bertho G, Charrier C, Ando K, Heymann D. Novel RANK antagonists for the treatment of bone-resorptive disease: theoretical predictions and experimental validation. J Bone Miner Res. 2014 ; 29(6):1466-77.  - (MNT team: INSERM UMR 957 - Nantes)
  • Gamblin AL, Brennan MA, Renaud A, Yagita H, Lézot F, Heymann D, Trichet V, Layrolle P. Bone tissue formation with human mesenchymal stem cells and biphasic calcium phosphate ceramics: The local implication of osteoclasts and macrophages. Biomaterials. 2014; 35;9660-7 - (MNT team: INSERM UMR 957 - Nantes)
  • Lamoureux F & Rédini F. Blocking clusterin inhibits emergence of resistance to zoledronic acid in osteosarcoma. Cancer Cell & Microenvironment Vol 1, No 4 (2014) - (MNT team: INSERM UMR 957 - Nantes)